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While there is emerging evidence that vector host immune responses are altered during filarial nematode infection, the potential parasite-derived effectors that might be driving this modulation and their mechanisms of action are undefined

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We and others showed that administration of LAC leads to a rapid regulation of plasticity of brain areas such as the hippocampus and the connected prefrontal cortex, which are implicated in MDD and are among the first brain structures to degenerate in Alzheimers Disease (AD) [26, 30, 34,35,36, 45]

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